Review: Unlicensed NK Cells Target Neuroblastoma Following Anti-GD2 Antibody Treatment

Review: Unlicensed NK Cells Target Neuroblastoma Following Anti-GD2 Antibody Treatment Author: Tarek, N., et al. J. Clin. Invest. 2012; 122(9): 3260-3270. doi:10.1172/JCI62749. Background: Neuroblastoma (NB) is the most common childhood extracranial solid tumor. Nearly two-thirds of diagnosed patients exhibit poor long-term survival despite aggressive treatment approaches. Treatment with monoclonal antibodies against the disialoganglioside surface antigen GD2 has resulted in lower recurrence and improved survival. The anti-GD2 mAb 3F8 utilizes antibody-dependent cell-mediated toxicity (ADCC) via myeloid and natural killer (NK) cells to kill the neuroblastoma. […]

By |2012-10-19T11:57:25+00:00October 19th, 2012|Categories: Publication Review|0 Comments

Therapeutic Potential of HIV Protease-Activable CASP3

Therapeutic Potential of HIV Protease-Activable CASP3 Authors: Kosuke Miyauchi, Emiko Urano, Mari Takizawa, Reiko Ichikawa, Jun Komano Scientific Reports 2012; 2: 359; doi:10.1038/srep00359.   Background: As the primary executioner caspase involved in apoptosis, Caspase-3 is a key therapeutic target in cancer cells exhibiting uncontrolled cell proliferation. Because Caspase-3 activation is highly regulated, development of a viable treatment method has been difficult.  Recent gene therapy procedures have been effective against HIV-1 infection, but development of treatment resistance due to mutation is a problem. Negative effects on healthy cells is also a problem. […]

By |2012-08-31T09:45:55+00:00August 31st, 2012|Categories: Publication Review|0 Comments

Direct Comparison of Different Stem Cell Types and Subpopulations Reveals Superior Paracrine Potency and Myocardial Repair Efficacy with Cardiosphere-Derived Cells

Direct Comparison of Different Stem Cell Types and Subpopulations Reveals Superior Paracrine Potency and Myocardial Repair Efficacy With Cardiosphere-Derived Cells Authors: Tao-Sheng Li, PhD., Ke Cheng, PhD., Konstantinos Malliaras, MD, et al. Journal of the American College of Cardiology 2012; 59(10): 942-953; doi:10.1016/j.jacc.2011.11.029. Background: Many types of stem cells have been used clinically in attempts to treat damaged hearts. The discovery of cardiac stem cells within the heart and the development of a technique for expansion of cardiosphere-derived cells (CDCs) has given researchers a new option in the use of stem cells for regenerative therapy. Purpose: To evaluate the success [...]

By |2012-06-21T12:05:05+00:00June 21st, 2012|Categories: Publication Review|0 Comments

Exploring Long-term Protection of Normal Human Fibroblasts and Epithelial Cells from Chemotherapy in Cell Culture

Exploring Long-term Protection of Normal Human Fibroblasts and Epithelial Cells from Chemotherapy in Cell Culture Authors: Pasha Apontes, Olga V. Leontieva, Zoya N. Demidenko, Fengzhi Li, Mikhail V. BlagosklonnyOncotarget. 2011 March 2(3): 222-233; PMCID: PMC3260824 Background: Microtubule-targeting agents or mitotic inhibitors are commonly used in chemotherapy for cancer. These agents kill proliferating, or cycling, cells by causing fatal mitotic arrest. Because many normal cells cycle very frequently (bone marrow cells, hair follicles, mucosal cells, endothelial cells), these normal cells are also affected by chemotherapy, leading to many side effects and reduced chemotherapy treatment. […]

By |2012-03-28T13:46:38+00:00March 28th, 2012|Categories: Publication Review|0 Comments