Oregon Health & Science University researchers continued their studies into the gender-related differences in peripheral immune system response after stroke that produce greater downstream damage in males than females, and what role the spleen may play in those differences. The goal of this work was to uncover which subset of immune system cells may contribute to those pathogenic effects after a stroke and how they vary by gender. Using primary leukocytes from transgenic mice and adoptive T-cell transfer, scientists injected specific cell types into splenectomized male and female mice 24 hours after stroke was induced. The Cellometer Auto T4 maintained cell counts. The data suggest that CD4/CD8/CD11b-injected mice showed no significant pathogenic differences than the vehicle-injected mice, leading researchers to believe there are other factors, either from the spleen or peripheral immune system, that are causing these variations in pathogenesis following stroke.
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