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Image-Based Analysis of Cell Cycle Using PI

The process of DNA replication and cell division is
known as the cell cycle. The cell cycle is typically
divided into five phases: G0, the resting phase, G1,
the normal growth phase, S, the DNA replication
phase, G2, involving growth and preparation for
mitosis, and M, mitosis.

There are at least two types of cell cycle control
mechanisms. The first involves kinase activation
to relay a cell from one stage to the next. The
second is a type of checkpoint control by which
flaws in critical events trigger a delay in cell cycle
progression. Because cell cycle events regulate cell
proliferation and cancer involves inappropriate
cell proliferation, cell cycle and alterations to the
cell cycle control mechanisms are at the heart of
oncology research1.

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