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Rapid, cell-based in situ cell
health assessments

Assays of cell health are the most common assays performed
in cell biology. Cell health assays are fundamental to early
drug safety evaluation in drug discovery as well as in general
maintenance of cells in culture and basic research. Cell health
assays fall generally into the categories of cell proliferation,
cell stress, apoptosis, and toxicity. Most of these types of assays
are usually performed using plate readers without access to
cell-level information. By contrast, many high content analysis
systems include cell health assays which do provide cell-level
data using high-resolution analysis, but are time-consuming and
require significant training to execute. The Celigo cytometer is
an easy alternative platform for a wide variety of cell health
assays providing cell-level information while maintaining the
simplicity of conventional plate reader assays.

The Celigo™ Cytometer is a microplate-based brightfield and
fluorescent imaging system designed to rapidly visualize,
identify, and quantify cell-based assays at the single-cell level.
Celigo enables fast imaging of entire wells (Fig. 1) of microplates
(6-well to 384-well plates) while maintaining consistent
illumination and contrast out to the well edge for accurate
identification of all cells within the well. This application note
demonstrates the use of several fluorescent cell health assays on
Celigo.

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