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Isolation, Quantitation and Viability Analysis of Neonatal Cardiomyocytes using Cellometer

The neonatal rat cardiomyocyte model has been
used for many years by researchers studying the
heart. In addition to increasing understanding
of the morphological, biochemical, and
electrophysiological characteristics of the normal
heart, neonatal cardiomyocytes have been used
to study contraction, ischemia, hypoxia, and the
toxicity of different compounds. This model has
been used to determine the optimal dosage for
certain drugs and to develop and evaluate the
efficacy of potential therapeutic agents. Apoptosis,
or programmed cell death, has been observed in
infarcted and re-perfused myocardium, end stages
of heart failure, post-infarction left ventricular
remodeling, and diabetes, making apoptosis
a key focus in the neonatal rat cardiomyocyte
model. In recent years, research into cellular
therapy and regenerative medicine has increased.
Studies involving the transplant of neonatal rat
cardiomyocytes into adult rats following cardiac
infarction have generated positive results, yielding
improvement in local tissue and overall cardiac
function.

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