Cellometer M10 studies evolutionarily-conserved proteins across species

The Max Planck Institute of Molecular Plant Physiology (Germany) investigated the evolutionarily-conserved proteins REIL 1 and 2 in A. thaliana and yeast cells. Research suggests these proteins are involved in the eukaryotic ribosomal 60S subunit. Here, investigators studied mutated REIL proteins in different species. The Cellometer Auto M10 analyzed cell size and concentration. The group discovered that these proteins are necessary to allow A. thaliana to grow in lower temperatures. Read the full publication here. 

Cellometer Auto T4 evaluates the cytotoxic potential of mouth rinses

How safe is your mouthwash? Researchers in Germany worked to answer that question. University of Leipzig (Germany) researchers investigated the cytotoxic effects of different antimicrobial mouth rinses (MRs) on gingival fibroblasts and epithelial cells. Although effective at killing infectious agents, most MRs have some cytotoxic impact on host tissue, which could delay the healing process the rinses are meant to enable. Human primary gingiva fibroblasts and human primary nasal epithelial cells were exposed to various MRs (Octenidol (OCT), Chlorhexidine 0.2% (CHX), Listerine (LIS), Meridol (MER), Betaisodona (BET), and control) for varying lengths of time. The Cellometer Auto T4 analyzed cell [...]

Cellometer helps to elucidate underlying mechanism of hypomyelination

Vanderbilt University researchers sought to evaluate the role of mTor signaling during myelination. Other work suggests that myelin abnormalities may be distinct from cortical lesions, and these scientists investigated the underlying mechanisms of hypomyelination to support or refute the other data. Primary astrocytes from knock out mouse pups were isolated to ascertain whether the astroglyosis seen in these mouse models is a specific or non-specific consequence of altered oligodendrocyte structure. Cellometer analyzed spherical size of these cells during experimentation. Although the findings suggest it is a nonspecific response, more study is clearly needed. These findings also suggest a dissociation between [...]

By |2021-06-15T19:43:40+00:00December 10th, 2015|Categories: Cellometer, Cellometer User Publications, Instrument|Tags: , |0 Comments
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