Cytopathic effects of Zika virus on HMC3 and JEG-3 cells measured by fluorescent viability dyes
The Celigo Image Cytometer can utilize fluorescent viability dyes to measure CPE. Researchers from the J. Craig Venter Institute characterized the time-course CPE effect of the Zika virus in placenta and microglia cells by measuring the green (live) and red (dead) fluorescent signals to show where healthy host cells remain after viral infection (read the paper here).
The time-course CPE effect calculated from plaque formation units per milliliter for HMC3 and JEG-3 host cells.
Example CPE measurement performed using the Celigo Image Cytometer: