ATR mutation sensitizes colorectal cancer cells to replication stress
The ATR-CHK1 pathway plays a critical role as a replication checkpoint and is a promising target for emerging therapies.
Age-Related Immune Response Heterogeneity to SARS-CoV-2 Vaccine BNT162b2
With new variants and waning immunity occurring, especially in elderly and immunocompromised individuals, it is important to understand how to utilize the tools we have to prevent severe disease and death.
New Advances in Cytotoxicity Assay Workflows using the Celigo Imaging Cytometer
The Celigo Image Cytometer has been previously used for a wide range of immuno-oncology and immunotherapy studies, demonstrating the great utility of this instrument to assess the activity of cytotoxic immune cells against malignant cells of interest.
Sangivamycin is highly effective against SARS-CoV-2 in vitro and has favorable drug properties
Sangivamycin is an unsuccessful anti-cancer drug candidate that has proven to be a potent inhibitor of multiple viruses. The authors of this study hypothesized that this compound would also be active against SARS-CoV-2.
PerkinElmer Unveils Industry-first Cell Analysis Solution to Streamline Cell and Gene Therapy Research and Manufacturing
PR Teaser: WALTHAM, Mass.--(BUSINESS WIRE)-- PerkinElmer, Inc., (NYSE: PKI), a global leader committed to innovating for a healthier world, today launched the Cellaca® PLX Image Cytometry System, a first-of-its-kind benchtop platform that enables researchers to assess multiple Critical Quality Attributes (CQAs) of cell samples in a single automated workflow, including cell identity, quality and quantity. Read the full press release »
Your cell counts will never be perfect – here’s why
“Biological variation” is an easy explanation to reach for when repeated measurements don’t match up very well. It is vague enough to excuse inconsistency in nearly any biological experiment, and in many cases, it is difficult to disprove.
Study finds a possible link between BCCIP and poor patient prognosis in lung adenocarcinoma
Starting with a bioinformatics approach using publicly available databases, the authors were able to confirm that tissues from patients with lung adenocarcinoma had increased expression of BCCIP and that high expression levels of BCCIP were correlated with poor patient prognosis.
T cell immunotherapy workflow improvements for clinical-grade manufacturing
Cell-based treatments are life-saving therapies with the potential to offer cures for cancers and other diseases.
Designing high-content tumor spheroid drug screening using high-throughput image cytometry
Solid tumor biology has become a critical step in accessing the potency of many cancer drugs. 3D spheroids and organoids can provide measurements such as size differences under drug conditions or metabolism and diffusion rates critical to drug development.
Repurposing immune cells to develop new therapies
For the development of new drugs and the advancement of new cell therapies, pharmaceutical companies have recurred to cytotoxicity assays as a quick way to assess the viability of cell lines in response to an external stimulus.
