Strategies for selecting accurate and precise cell viability detection methods for cell therapy development and manufacturing

Cellular therapy harnesses the unique properties of cells to restore, repair, or replace damaged tissues or organs in the body. There are various types of cellular therapies, including stem cell therapies, CAR T-cell therapies, and other immunotherapies, that hold great potential in the treatment and prevention of a wide variety of diseases. The International Organization for Standardization (ISO) has issued guidance on Critical Quality Attributes (CQAs) essential for assessing and approving cellular therapeutic products. These attributes are critical for ensuring the safety, efficacy, and quality of therapeutic products. One CQA that is integral to cellular therapy development is [...]

By |2024-01-12T18:04:40+00:00January 11th, 2024|Categories: Cellaca, Instrument, Latest News|0 Comments

How to improve cell counting processes for accurate cell characterization

Guidance on improving the quality of cell counting results to increase confidence amongst the inherent challenges when working with live cells.

What is Image Cytometry?

Image cytometry and how it compares to other methods. Improve the quality of cell counting results to increase confidence in processes and workflows.

SCARA5 Promotes Proliferation and Migration of Esophageal Squamous Cell Carcinoma

Exploration of candidate genes responsible for esophageal squamous cell carcinoma (ESCC) pathogenesis may provide insight into the underlying signaling pathways to uncover novel therapeutic targets.

ATR mutation sensitizes colorectal cancer cells to replication stress

The ATR-CHK1 pathway plays a critical role as a replication checkpoint and is a promising target for emerging therapies.

Age-Related Immune Response Heterogeneity to SARS-CoV-2 Vaccine BNT162b2

With new variants and waning immunity occurring, especially in elderly and immunocompromised individuals, it is important to understand how to utilize the tools we have to prevent severe disease and death.

New Advances in Cytotoxicity Assay Workflows using the Celigo Imaging Cytometer

The Celigo Image Cytometer has been previously used for a wide range of immuno-oncology and immunotherapy studies, demonstrating the great utility of this instrument to assess the activity of cytotoxic immune cells against malignant cells of interest.

Sangivamycin is highly effective against SARS-CoV-2 in vitro and has favorable drug properties

Sangivamycin is an unsuccessful anti-cancer drug candidate that has proven to be a potent inhibitor of multiple viruses. The authors of this study hypothesized that this compound would also be active against SARS-CoV-2.

Your cell counts will never be perfect – here’s why

“Biological variation” is an easy explanation to reach for when repeated measurements don’t match up very well. It is vague enough to excuse inconsistency in nearly any biological experiment, and in many cases, it is difficult to disprove.

By |2022-09-09T14:23:52+00:00September 9th, 2022|Categories: Accurate Cell Counting, Cell Counting Leadership, Latest News, Uncategorized|Tags: |0 Comments

Study finds a possible link between BCCIP and poor patient prognosis in lung adenocarcinoma

Starting with a bioinformatics approach using publicly available databases, the authors were able to confirm that tissues from patients with lung adenocarcinoma had increased expression of BCCIP and that high expression levels of BCCIP were correlated with poor patient prognosis.

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