SCARA5 Promotes Proliferation and Migration of Esophageal Squamous Cell Carcinoma

Exploration of candidate genes responsible for esophageal squamous cell carcinoma (ESCC) pathogenesis may provide insight into the underlying signaling pathways to uncover novel therapeutic targets.

ATR mutation sensitizes colorectal cancer cells to replication stress

The ATR-CHK1 pathway plays a critical role as a replication checkpoint and is a promising target for emerging therapies.

Study finds a possible link between BCCIP and poor patient prognosis in lung adenocarcinoma

Starting with a bioinformatics approach using publicly available databases, the authors were able to confirm that tissues from patients with lung adenocarcinoma had increased expression of BCCIP and that high expression levels of BCCIP were correlated with poor patient prognosis.

Designing high-content tumor spheroid drug screening using high-throughput image cytometry

Solid tumor biology has become a critical step in accessing the potency of many cancer drugs. 3D spheroids and organoids can provide measurements such as size differences under drug conditions or metabolism and diffusion rates critical to drug development.

A rapid method to establish potential molecular targets for colorectal cancer progression

The development of targeted molecular therapies is an increasingly popular approach to combat and overcome the limitations of conventional treatments.

Identifying Downstream Candidates for Targeted Molecular Therapy

A fundamental understanding of the molecular mechanisms responsible for the development and progression of RCC will be pivotal in developing next-generation treatment protocols to improve patient outcomes.

Webinar on Demand: Advanced In-vitro Cancer Models to Study Tumor Microenvironment

During this webinar we will highlight a variety of assays to study the tumor microenvironment

Cellometer assists in search to combat tumor radio-resistance

At the University of Luebek (Germany), scientists investigated how a mechanism of tumor hypoxia - Aryl hydrocarbon receptor nuclear translocator (ARNT), a transcription factor also known as hypoxia-inducible factor (HIF)-1β - increases a tumor’s resistance to radiation therapy. ARNT expression was knocked out with siRNA or overexpressed using a plasmid vector in a variety of human tumor cell lines such as Hep3B, MCF-7, 786-Owt, 786-Ovhl, RCC4wt and RCC4vhl before exposure to X-irradiation. The Cellometer and Trypan Blue were used to establish cell counts. Researchers found that a reduction of ARNT expression made all cell lines more susceptible to X-irradiation, whereas [...]

Establishment of Human Ultra-Low Passage Colorectal Cancer Cell Lines Using Spheroids from Fresh Surgical Specimens Suitable for In Vitro and In Vivo Studies

Human primary colon cancer cells digested from tumor used to establish ultra-low passage colorectal cancer cell lines. Cell count and viability were determined by the trypan blue dye exclusion method using a T4 Cellometer (Nexcelom Bioscience LLC, USA). […]

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