New Advances in Cytotoxicity Assay Workflows using the Celigo Imaging Cytometer

The Celigo Image Cytometer has been previously used for a wide range of immuno-oncology and immunotherapy studies, demonstrating the great utility of this instrument to assess the activity of cytotoxic immune cells against malignant cells of interest.

Sangivamycin is highly effective against SARS-CoV-2 in vitro and has favorable drug properties

Sangivamycin is an unsuccessful anti-cancer drug candidate that has proven to be a potent inhibitor of multiple viruses. The authors of this study hypothesized that this compound would also be active against SARS-CoV-2.

Study finds a possible link between BCCIP and poor patient prognosis in lung adenocarcinoma

Starting with a bioinformatics approach using publicly available databases, the authors were able to confirm that tissues from patients with lung adenocarcinoma had increased expression of BCCIP and that high expression levels of BCCIP were correlated with poor patient prognosis.

Designing high-content tumor spheroid drug screening using high-throughput image cytometry

Solid tumor biology has become a critical step in accessing the potency of many cancer drugs. 3D spheroids and organoids can provide measurements such as size differences under drug conditions or metabolism and diffusion rates critical to drug development.

A rapid method to establish potential molecular targets for colorectal cancer progression

The development of targeted molecular therapies is an increasingly popular approach to combat and overcome the limitations of conventional treatments.

Identifying Downstream Candidates for Targeted Molecular Therapy

A fundamental understanding of the molecular mechanisms responsible for the development and progression of RCC will be pivotal in developing next-generation treatment protocols to improve patient outcomes.

Cell counting: A practical guide to evaluating cell counting methods

Because there is no certified reference material to determine cell concentration, ISO cell counting standards are a valuable tool for evaluating and selecting fit-for-purpose cell counting methods.

Innovative Cytotoxicity Assays Utilizing Imaging Cytometry to Investigate Anti-Tumor Immunity

The ongoing pursuit of novel anti-cancer therapeutics must consider the potential for off-target effects on the immune system.

High-Throughput Imaging Cytometry for Rapid Investigation in the Role of MEX3A in Glioma

The researchers in this study first utilized various techniques to explore the role of MEX3A in glioma, including immunohistochemistry to assess MEX3A expression levels in glioma tissues, knockdowns of MEX3A in conjunction with a transwell assay to assess migration and an in-vivo mouse model of tumor burden.

By |2022-01-19T19:38:13+00:00January 19th, 2022|Categories: Celigo, Latest News, Neurology|Tags: , , , |0 Comments

High-Throughput Imaging Assessing Virus-Neutralizing Activity of Sera from Vaccinated Individuals

The severe acute respiratory coronavirus 2 (SARS-CoV-2) has caused the ongoing COVID-19 pandemic, infecting more than 206 million people and causing upwards of 4.34 million deaths at the time of writing.

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