With new variants and waning immunity occurring, especially in elderly and immunocompromised individuals, it is important to understand how to utilize the tools we have to prevent severe disease and death.
The Celigo Image Cytometer has been previously used for a wide range of immuno-oncology and immunotherapy studies, demonstrating the great utility of this instrument to assess the activity of cytotoxic immune cells against malignant cells of interest.
Sangivamycin is an unsuccessful anti-cancer drug candidate that has proven to be a potent inhibitor of multiple viruses. The authors of this study hypothesized that this compound would also be active against SARS-CoV-2.
Perform simultaneous imaging and analysis to rapidly capture and quantify spheroid images in every well with advanced software segmentation.
Establishing a High-throughput Screening Platform for NK mediated Cytotoxicity using Image Cytometry
Researchers highlight the need for large-scale screening of cytotoxic cells and their ability to kill target cell lines in both a 2D and 3D fashion.
Monoclonal cell culture is critical for many research areas however, the process to establish monoclonal cell lines is time-consuming, and many methods used to monitor monoclonality of cell culture still rely on manual and low-throughput methods.
Many leading labs in the field of virology have used the Celigo Image Cytometer to directly measure multiplex cell-based assays in real-time.
Watch the demo on demand: Modern Cell-based Assays for Cell and Gene Therapy Using Image Cytometry
Detection of novel CD276-CAR NK-92 mediated cytotoxicity of neuroblastoma tumor spheroids using plate-based image cytometry
Drug repurposing, also known as drug repositioning is a powerful tool for the rapid expansion of available therapy options by identifying new therapeutic uses from pre-existing drugs.