T cell immunotherapy workflow improvements for clinical-grade manufacturing
Cell-based treatments are life-saving therapies with the potential to offer cures for cancers and other diseases.
Designing high-content tumor spheroid drug screening using high-throughput image cytometry
Solid tumor biology has become a critical step in accessing the potency of many cancer drugs. 3D spheroids and organoids can provide measurements such as size differences under drug conditions or metabolism and diffusion rates critical to drug development.
Repurposing immune cells to develop new therapies
For the development of new drugs and the advancement of new cell therapies, pharmaceutical companies have recurred to cytotoxicity assays as a quick way to assess the viability of cell lines in response to an external stimulus.
A rapid method to establish potential molecular targets for colorectal cancer progression
The development of targeted molecular therapies is an increasingly popular approach to combat and overcome the limitations of conventional treatments.
Identifying Downstream Candidates for Targeted Molecular Therapy
A fundamental understanding of the molecular mechanisms responsible for the development and progression of RCC will be pivotal in developing next-generation treatment protocols to improve patient outcomes.
Cell counting: A practical guide to evaluating cell counting methods
Because there is no certified reference material to determine cell concentration, ISO cell counting standards are a valuable tool for evaluating and selecting fit-for-purpose cell counting methods.
Innovative Cytotoxicity Assays Utilizing Imaging Cytometry to Investigate Anti-Tumor Immunity
The ongoing pursuit of novel anti-cancer therapeutics must consider the potential for off-target effects on the immune system.
High-Throughput Imaging Cytometry for Rapid Investigation in the Role of MEX3A in Glioma
The researchers in this study first utilized various techniques to explore the role of MEX3A in glioma, including immunohistochemistry to assess MEX3A expression levels in glioma tissues, knockdowns of MEX3A in conjunction with a transwell assay to assess migration and an in-vivo mouse model of tumor burden.
Instrument-to-Instrument Variability: A hidden reason your protocol may not work in other labs
For many other types of measurement, close agreement between instruments is achieved by calibration to a reference standard. Some examples include the calibration of a group of analytical balances to a single reference mass and calibration of pH meters to a precisely prepared buffer solution.
High-Throughput Imaging Assessing Virus-Neutralizing Activity of Sera from Vaccinated Individuals
The severe acute respiratory coronavirus 2 (SARS-CoV-2) has caused the ongoing COVID-19 pandemic, infecting more than 206 million people and causing upwards of 4.34 million deaths at the time of writing.